25^ème Rencontres en Toxinologie de la Société Française pour l'Etude des Toxines (SFET)

" Toxines et Santé : des molécules aux organismes "

28 et 29 novembre 2018 - Institut Pasteur ( Auditorium François Jacob)
Paris - France

" Toxins and Health: from molecules to organisms "

Wednesday 28^th November 

9h10 - 11h30  Session 1 |
Strategies for screening toxins : Pascale MARCHOT & Nicolas GILLES

• 9h10 - 9h40: Jeroen KOOL (Amsterdam Institute for Molecules Medicines and Systems, Amsterdam, The Netherlands)

          Analytics for assessing venom coagulopathy and neurotoxicity

• 9h40 - 10h10: Jean‐Marie CHAMBARD (Sanofi R&D, Integrated Drug Discovery – High Content Biology, Vitry‐sur‐Seine, France) 

• 10h10 - 10h40: Coffee break & Posters
• 10h40 - 11h10: Nicolas GILLES (SIMOPRO, CEA de Saclay, Gif‐sur‐Yvette, France) 

• 11h10 - 11h30: Kévin PROLA (Université de Strasbourg, Institut de Bactériologie, Strasbourg, France) 

          Characterization of a potential virulence factor zinc metallopeptidase produced
          by Staphylococcus lugdunensis  

• 11h30 - 11h40: Sponsor presentation (domiconus: 1^st European Conidae venom library for pharmaceutical research)
• 11h40 - 12h15: Posters as 3-min highlights (limited to 12 posters)
• 12h15 - 12h30: Group photo 
• 12h30 - 14h30: Lunch & Posters

14h30 - 17h00 Session 2 |
Toxin‐induced pathologies : Michel POPOFF & Gilles PREVOST

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• 14h30 - 15h00: Kim ROELANTS (Amphibian Evolution Lab, Vrije Universiteit Brussel, Elsene, Belgium) 
  Poison from a frog's perspective: Tracing the evolution and adaptive roles of anuran antimicrobial peptides
• 15h00 - 15h30: Pal STENMARK (Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden)
  The clostridial neurotoxins, a growing family
• 15h30 - 16h00: Gabriella VIERO (Institute of Biophysics, CNR Unit, Trento, Italy)
   A host lncRNAs protects human cells from bacterial infection and aids against infection by associating with polysomes 
• 16h00 - 16h20: Horst POSTHAUS (Institute of Animal Pathology, Department of Infectious Diseases and Pathobiology, Vetsuisse-Faculty, University of Bern, Switzerland)
  New insights into the role of beta toxin in Clostridium perfringens type C enteritis
• 16h20 - 16h40: Geoffrey MASUYER (Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden)
  The structure of the tetanus toxin reveals pH mediated domain dynamics
• 16h40 - 17h00: Christian LEGROS (Institut MITOVASC, Université d'Angers, Angers, France)
  Activation of Na_v channels with neurotoxins reveals a cross-talk between Na_v1.3, L-type Ca_v channels and Na⁺/Ca²⁺ exchanger in GH3b6 cells
  
• 17h00 - 19h00: General Assemby of the  SFET (SFET members)

Thursday 29^th November 

9h00 - 12h00 Session 3 |
Toxins as therapeutics : Grazyna FAURE & Denis SERVENT

• 9h00 – 9h30: Christian GRUBER (Center for Physiology and Pharmacology, Medical University of Vienna, Austria)
  Plant cystine knot peptide toxins as pharmacological research tools and therapeutic drug candidates
• 9h30 – 10h00: Antonio VILLAVERDE (Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Spain)
  Engineering protein toxins as self assembling, self delivered antitumoral drugs
• 10h00 – 10h20: Johannes KRUPP (Ipsen Innovation, Les Ulis, France)
  Increased affinity of engineered botulinum neurotoxin B to its human receptors translate into increased clinical potential 
• 10h20 – 10h40: Coffee break & Posters 
• 10h40 – 11h00: Julien GIRIBALDI (Institut des Biomolécules Max Mousseron, Université de Montpellier - CNRS, Montpellier, France)
  Backbone cyclization of native α-conotoxin CIA dramatically increases affinity at neuronal nicotinic receptors  
• 11h00 – 11h20: Grazyna FAURE (Unité Récepteurs Canaux, Institut Pasteur, Paris, France)
  Potential applications of snake venom PLA2 toxins for drug design
• 11h20 - 11h40: Jérome MONTNACH (Institut du thorax, Nantes, France)
  High-throughput automated patch-clamp: Modulation of αC-conotoxin pharmacology by aptamers
• 11h40 - 12h00: Sylvie DIOCHOT (Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France)
  Inhibition of ASIC1 channels in a rat model of migraine induces potent analgesic effects
• 12h00 – 12h15: Ceremony for best poster and other awards 
• 12h15 – 14h00: Lunch & Posters

15h00 – 16h20 Session 4 | 

Miscellaneous : Evelyne BENOIT & Julien BARBIER

• 14h00 – 14h20: Marie Yasmine DECHRAOUI BOTTEIN (Environment Laboratories, Department of Nuclear Science and Application, International Atomic Energy Agency, Monaco)
  Detection toxicity and bioaccumulation of ciguatoxins in fish
• 14h20 - 14h40: Khadija DAOUDI (Pasteur Institute of Morocco, Laboratory of Venoms and Toxins, Casablanca, Morocco)
  Exhaustive characterization of Moroccan scorpion venoms by the proteomic approach "Mass spectrometry" 
• 14h40 - 15h00:  Alexandre CHENAL (Structural Biology and Chemistry Department, Institut Pasteur, Paris, France)
  Structural flexibility of CyaA is crucial for its secretion, folding and host cell hijacking 
• 15h00 - 15h20: Laure GUENIN-MACE (Unité d'Immunologie de l'Infection, Institut Pasteur, Paris, France)
  Mycolactone-mediated SEC61 blockade prevents inflammatory reponses in the nervous system 
• 15h20 - 15h40: Christine RASETTI-ESCARGUEIL (Microbiology Department, Institut Pasteur, Paris, France)
  Development of innovative BoNT antibodies and progress toward harmonization of the detection of BoNT toxins  
• 15h40 - 16h00: Fanny NOIRMAIN (SIMOPRO, CEA de Saclay, Gif‐sur‐Yvette, France
  Fast and early warning lateral flow test for the detection of neurotoxins targeting nicotinic acetylcholine receptors
• 16h00 - 16h20: Salma CHAKIR (Pasteur Institute of Morocco, Laboratory of Venoms and Toxins, Casablanca, Morocco) 
  Comparative study of the histological changes induced by the venoms of Cerastes cerastes and Naja haje legionis
• 16h20 - 16h30: Closure Evelyne BENOIT (SFET President)