"Toxins: New Targets and New Functions"

Session 1 | Toxins acting on Nervous system

Emmanuel BOURINET
Ion Channel Science and Therapeutics. Institut de Génomique Fonctionnelle, Université de Montpellier, France
Low-voltage gated calcium channels in pain pathways: from mechanisms to toxin identification

Eugene GRISHIN
Laboratory of neuroreceptors and neuroregulators, Moscow, Russia
Spider toxins active on purinergic P2X3 receptor
Christian LEGROS
BNMI, UMR CNRS 6214 – UMR INSERM 1083, Angers, France
Voltage-sensor probes as efficient tools to screen for new modulators of voltage-gated sodium channels
Yara CURY
Laboratório Especial de Dor e Sinalização, Instituto Butantan, São Paulo, SP, Brazil
Peripheral interactions between cannabinoid and opioid systems contribute to the antinociceptive effect of crotalphine

Grazyna FAURE
Institut Pasteur, Paris, France
Crotoxin: New targets and new functions
Killian L'HERONDELLE
Université de Bretagne Occidentale, Brest, France
Study of the involvement of itch mediators in the neuropeptide release induced by Pacific-Ciguatoxin-2 in a co-culture model of sensory neurons and keratinocytes
Laurent MARSOLLIER
Centre de Recherche en Cancérologie Nantes Angers, Université d’Angers, France
High content chemical and genetic screening reveal that analgesia in Buruli ulcer is induced by mycobacterial toxin targeting angiotensin pathways

Cesare MONTECUCCO
Department of Biomedical Sciences, University of Padova, Italy
Animal presynaptic neurotoxins provide a relevant novel model of moto axon terminal degeneration followed by regeneration
Domenico AZARNIAN TEHRAN
Department of Biomedical Sciences, University of Padova, Italy
Thioredoxin and its reductase are present on synaptic vesicles and their inhibition prevents the paralysis induced by botulinum neurotoxin

Klaus AKTORIES
Institute for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany
PaTox: A new bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins
Undine MECHOLD
Institut Pasteur, Paris, France
ExoY, a nucleotidyl cyclase toxin from Pseudomonas aeruginosa
Jean-Philippe NOUGAYREDE
Inserm, UMR1043, Toulouse, France
The genotoxin colibactin
Holger BARTH
Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Ulm, Germany
Role of host cell chaperones in cellular uptake of binary clostridial enterotoxins
Neetu GUPTA
CEA, iBiTec-S, SIMOPRO, Gif sur Yvette, France
Inhibitors of intracellular trafficking active against Shiga toxin and ricin

Diane BRINKMAN
Australian Institute of Marine Science, Townsville, Australia
Variable cardiovascular effects of Chironex fleckeri (box jellyfish) toxins
Nicolas GILLES
Toxins, Receptors and Channels Group, CEA/ibiTecS/SIMOPRO. Gif sur Yvette. France
Activity of Mambaquaretin toxin on kidney disease via its interaction with Vasopressin V2 receptor
Gérard LAMBEAU
Institute of Cellular and Molecular Pharmacology. Université de Nice-Sophia-Antipolis, Valbonne, France
The family of venom and mammalian sPLA2s : from toxic to therapeutic enzymes
Imen JRIDI
Institut Pasteur of Tunis, Tunis, Tunisia
Purification and characterization of two novel Hemiscorpius Lepturus scorpion venom-derived phospholipases A2 which inhibit angiogenesis in vitro

Denise TAMBOURGI
Immunochemistry Laboratory, Butantan Institute, São Paulo, SP, Brazil
Loxosceles Sphingomyelinase D induces leukocyte activation which is partially complement dependent: similarities to endotoxic shock
Gaëlle ZIMMERMANN-MEISSE
Université de Strasbourg, EA7290, Strasbourg, France
The staphylococcal Panton and Valentine Leukocidin and γ-haemolysin HlgC/HlgB share C5aR as a receptor, but operate diverse intracellular activities in human polymorphonuclear neutrophils

Patrick JIMONET
Sanofi, LGCR, Vitry sur Seine, France
Venoms as source of active peptides: an attractive approach to drug challenging targets at Sanofi
Michel DEGUELDRE
University of Liege, Belgium
Diversity in sequences, folds and pharmacological activities of toxins from four Conus venoms revealed by the combination of cutting-edge technologies of proteomics, transcriptomics and bioinformatics

Emmanuel LEMICHEZ
Centre Méditerranéen de Médecine Moléculaire, Université de Nice-Sophia Antipolis, France
Transcellular tunnel dynamic: system model for studying actomyosin organization at newly curved plasma membrane
Alexandre CHENAL
Institut Pasteur, Paris, France
Deciphering protein membrane interactions involved in the translocation process of a bacterial toxin, the adenylate cyclase (CyaA) toxin from Bordetella pertussis
Daniel LAJOIE
University of Arizona, Tucson, AZ, USA
The chemistry and functional diversity of spider phospholipase D toxins
Romulo ARAOZ
Laboratoire de Neurobiologie et Développement, CNRS, Gif sur Yvette, France
Purification and characterization of hydrosoluble icthyotoxic compounds from the marine cyanobacterium Trichodesmium erythraeum collected in New Caledonia
Marion VERDONI
Institut de Chimie Radicalaire, Faculté des Sciences et techniques, Université Aix-Marseille, Marseille, France
Isolation and Characterization of a Natural Compound Extracted from Spider Venoms: a New Approach in Cosmetic to Treat Hyperpigmentation Disorders
Naoual OUKKACHE
Institut Pasteur du Maroc, Casablanca, Morocco
Characterization of two Moroccan scorpion venoms: proteomic analysis, neurotoxicity, myotoxicity and sensitivity to neutralization by commercial polyclonal antivenom

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