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RT25 (2018) : Toxins and health: from molecules to organisms |
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25th Meeting of the French Society of Toxinology (SFET)
"Toxins and health: from molecules to organisms"
November 28th-29th, 2018 - Institut Pasteur (Auditorium François Jacob)
Paris - France
Wednesday 28th November
9h00 - 9h10: Welcome. Evelyne BENOIT (SFET President)
9h10 - 11h30 Session 1 |
Strategies for screening toxins: Pascale MARCHOT & Nicolas GILLES
- 9h10 - 9h40: Jeroen KOOL (Amsterdam Institute for Molecules Medicines and Systems, Amsterdam, The Netherlands)
Analytics for assessing venom coagulopathy and neurotoxicity
- 9h40 - 10h10: Jean‐Marie CHAMBARD (Sanofi R&D, Integrated Drug Discovery – High Content Biology, Vitry‐sur‐Seine, France)
Venoms in Drug Discovery : A case study on voltage gated channels
- 10h10 - 10h40: Coffee break & Posters
- 10h40 - 11h10: Nicolas GILLES (SIMOPRO, CEA de Saclay, Gif‐sur‐Yvette, France)
How to turn the complexity of venoms into an HTS‐compatible toxin bank
- 11h10 - 11h30: Kévin PROLA (Université de Strasbourg, Institut de Bactériologie, Strasbourg. France)
Characterization of a potential virulence factor zinc metallopeptidase produced
by Staphylococcus lugdunensis
- 11h30 - 11h40: Sponsor presentation (domiconus: 1st European Conidae venom library for pharmaceutical research)
- 11h40 - 12h15: Posters as 3-min highlights (limited to 12 posters)
- 12h15 - 12h30: Group photo
- 12h30 - 14h30: Lunch & Posters
14h30 - 17h00 Session 2 |
Toxin‐induced pathologies: Michel POPOFF & Gilles PREVOST
- 14h30 - 15h00: Kim ROELANTS (Amphibian Evolution Lab, Vrije Universiteit Brussel, Elsene, Belgium)
Poison from a frog's perspective: Tracing the evolution and adaptive roles of anuran antimicrobial peptides
- 15h00 - 15h30: Pal STENMARK (Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden)
The clostridial neurotoxins, a growing family
- 15h30 - 16h00: Gabriella VIERO (Institute of Biophysics, CNR Unit, Trento, Italy)
A host lncRNAs protects human cells from bacterial infection and aids against infection by associating with polysomes
- 16h00 - 16h20: Horst POSTHAUS (Institute
of Animal Pathology, Department of Infectious Diseases and Pathobiology,
Vetsuisse-Faculty, University of Bern, Switzerland)
New insights into the role of beta toxin in Clostridium perfringens type C enteritis
- 16h20 - 16h40: Geoffrey MASUYER (Department
of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden)
The structure of the tetanus toxin reveals pH mediated domain dynamics
- 16h40 - 17h00: Christian LEGROS (Institut MITOVASC, Université d'Angers, Angers, France)
Activation of Nav channels with neurotoxins reveals a cross-talk between Nav1.3, L-type Cav channels and Na+/Ca2+ exchanger in GH3b6 cells
- 17h00 - 19h00: General Assemby of the SFET (SFET members)
Thursday 28th November
9h00 - 12h00 Session 3 |
Toxins as therapeutics: Grazyna FAURE & Denis SERVENT
- 9h00 – 9h30: Christian GRUBER (Center for Physiology and Pharmacology, Medical
University of Vienna, Austria)
Plant cystine knot peptide toxins as pharmacological research tools and therapeutic drug candidates
- 9h30 – 10h00: Antonio VILLAVERDE (Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de
Barcelona, Spain)
Engineering protein toxins as self assembling, self delivered antitumoral drugs
- 10h00 – 10h20: Johannes KRUPP (Ipsen Innovation,
Les Ulis, France)
Increased affinity of engineered botulinum neurotoxin B to its human receptors translate into increased clinical potential
- 10h20 – 10h40: Coffee break & Posters
- 10h40 – 11h00: Julien GIRIBALDI (Institut des Biomolécules Max Mousseron, Université de Montpellier - CNRS, Montpellier, France)
Backbone cyclization of native a conotoxin CIA dramatically increases affinity at neuronal nicotinic receptors
- 11h00 – 11h20: Grazyna FAURE (Unité Récepteurs Canaux, Institut Pasteur, Paris, France)
Potential applications of snake venom PLA2 toxins for drug design
- 11h20 - 11h40: Jérome MONTNACH (Institut du thorax, Nantes, France)
High-throughput automated patch-clamp: Modulation of αC-conotoxin pharmacology by aptamers
- 11h40 - 12h00: Sylvie DIOCHOT (Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France)
Inhibition of ASIC1 channels in a rat model of migraine induces potent analgesic effects
- 12h00 – 12h15: Ceremony for best poster and other awards
- 12h15 – 14h00: Lunch & Posters
15h00 – 16h20 Session 4 |
Miscellaneous: Evelyne BENOIT & Julien BARBIER
- 14h00 – 14h20: Marie Yasmine DECHRAOUI BOTTEIN (Environment
Laboratories, Department of Nuclear Science and Application, International
Atomic Energy Agency, Monaco)
Detection toxicity and bioaccumulation of ciguatoxins in fish
- 14h20 - 14h40: Khadija DAOUDI (Pasteur Institute of
Morocco, Laboratory of Venoms and Toxins, Casablanca, Morocco)
Exhaustive characterization of Moroccan scorpion venoms by the proteomic approach "Mass spectrometry"
- 14h40 - 15h00: Alexandre CHENAL (Structural Biology and Chemistry Department, Institut Pasteur, Paris, France)
Structural flexibility of CyaA is crucial for its secretion, folding and host cell hijacking
- 15h00 - 15h20: Laure GUENIN-MACE (Unité d'Immunologie de l'Infection, Institut Pasteur, Paris, France)
Mycolactone-mediated SEC61 blockade prevents inflammatory reponses in the nervous system
- 15h20 - 15h40: Christine RASETTI-ESCARGUEIL (Microbiology Department, Institut Pasteur, Paris, France)
Development of innovative BoNT antibodies and progress toward harmonization of the detection of BoNT toxins
- 15h40 - 16h00: Fanny NOIRMAIN (SIMOPRO, CEA de Saclay, Gif‐sur‐Yvette, France
Fast and early warning lateral flow test for the detection of neurotoxins targeting nicotinic acetylcholine receptors
- 16h00 - 16h20: Salma CHAKIR (Pasteur Institute of Morocco, Laboratory of Venoms and Toxins, Casablanca, Morocco)
Comparative study of the histological changes induced by the venoms of Cerastes cerastes and Naja haje legionis
- 16h20 - 16h30: Closure Evelyne BENOIT (SFET President)
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Last Updated ( lundi, 25 février 2019 )
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