23rd Meeting of the French Society of Toxinology (SFET)
"Toxins: Immunity, Inflammation and Pain"
5 et 6 Décembre 2016 - Institut Pasteur (Auditorium François Jacob)
Paris - France
9h10 - 12h45 : Session 1 | Toxins and Immunity
Chairmen : Michel DE WAARD & Lhousseine TOUQUI
- 9h10 - 9h40 : Lhousseine TOUQUI
Mucoviscidose et Bronchopathies Chroniques, Institut Pasteur, Paris, France
Immunomodulatory roles of bacterial toxins: impacts on the innate pulmonary
defense of the host
- 9h40 - 10h10 : Christine BEETON
Baylor College of Medicine, Houston, USA
Targeting potassium channels in rheumatoid arthritis
- 10h10 - 10h30 : Nassim MAHTAL
Service d’Ingénierie Moléculaire des Protéines, CEA de Saclay, Gif-sur-Yvette, France
High-Throughput Screening of Rac1 enhancers as stimulators of innate and acquired immunity
- 10h30 – 10h50: Fatima CHGOURY
Laboratoire des Venins et Toxines, Institut Pasteur du Maroc, Casablanca, Maroc
Paraspecific effect of Androctonus australis hector NbF12-10 nanobody against Moroccan scorpion venom
- 10h50 – 10h55: Conrad WEICHBRODT
Nanion Technologies GmbH, München, Germany
Next level toxicity screening: from single channel to overall cell behavior
- 10h55 – 11h25: Coffee break & Posters
- 11h25 – 11h55: Philipp HENNEKE
Center for Chronic Immunodeficiency, Freiburg, Germany
Macrophage subset development and environmental imprinting determine immunity in staphylococcal soft tissue infection
- 11h55 – 12h25: Philippe BULET
Plateforme BioPark d'Archamps, Archamps Technopole, Saint Julien en Genevois, France
Venom toxins and antimicrobial peptides: evidence that venom toxins are closely related to defensins of innate immunity
- 12h25 – 12h45: Michel DE WAARD
Institut du Thorax, Nantes, France
Efficient neutralization of deadly toxins in vivo by DNA oligonucleotides
- 12h45 – 14h30: Lunch & Posters
14h30 - 17H20: Session 2 | Toxins and Pain
Chairmen: Denis SERVENT & Eric LINGUEGLIA
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14h30 – 15h00: Laurence BOURGEAIS RAMBUR
Centre de Psychiatrie & Neurosciences, Paris, France
Functional architecture of pain pathways
- 15h00 – 15h30: Estelle MARION
ATOMyca, Angers, France
Mycolactone: the amazing analgesic mycobacterial toxin
- 15h30 – 15h50: Tânia C. GONÇALVES
Sanofi R&D, Vitry-sur-Seine, France
D peptide, a promising toxin as potential antinociceptive agent targeting the Nav1.7 subtype of voltage-gated sodium channels
- 15h50 – 16h20: Ren LAI
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
Centipede venom toxins acting on ion channels
- 16h20 – 16h50: Eric LINGUEGLIA
Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne, France
Acid-Sensing Ion Channels in the pain pathway or how animal toxins can help to understand pain
- 16h50 – 17h20: Mikhail KALINICHEV
Ipsen Innovation, Les Ulis, France
Exploiting the biology of botulinum neurotoxins for pain
- 17h30 – 19h00: General Assembly of the SFET (SFET members)
Session 3 | Toxins and Inflammation
Chairmen: Grazyna FAURE & Félix VIANA
- 9h00 – 9h30: Jean-Marc CAVAILLON
Unité Cytokines et Inflammation, Institut Pasteur, Paris, France
Exotoxins and endotoxins: inducers of inflammatory cytokines
- 9h30 – 10h00: Michel R. POPOFF
Unité des Bactéries anaérobies et Toxines, Institut Pasteur, Paris, France
Toxins of Clostridium sordellii and Clostridium difficile: the proinflammatory versus cytoprotective response
- 10h00 – 10h20: Joseph KHOURY
Biologie neurovasculaire et mitochondriale intégrée, Université d’Angers, France
The aqueous buds extract of Eucalyptus neutralizes the main enzymatic activities of Montivipera bornmuelleri venom
- 10h20 – 10h50: Coffee break & Posters
- 10h50 – 11h20: Michael HENEKA
Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Germany
Does neuroinflammation represent a promising therapeutic target in Alzheimer's disease?
- 11h20 – 11h50: Félix VIANA
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández y CSIC, Alicante, Spain
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
- 11h50 – 12h10: Jean-David MOREL
Unité d’Immunobiologie de l’Infection, Institut Pasteur, Paris, France
Host immunomodulation by mycolactone, the Mycobacterium ulcerans toxin
- 12h10 – 15h00: Lunch & Posters
Session 4| Miscellaneous
Chairmen: Sébastien DUTERTRE & Jordi MOLGÓ
- 15h00 – 15h20: Alexander BELYY
Unité de Biochimie des Interactions macromoléculaires, Institut Pasteur, Paris, France
Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin
- 15h20 – 15h40: Naoual OUKKACHE
Laboratoire des Venins et Toxines, Institut Pasteur du Maroc, Casablanca, Maroc
Characterization of Am IT, an anti-insect β-toxin isolated from the venom of scorpion Androctonus mauretanicus
- 15h40 – 16h00: Laura DROCTOVE
Service d’Ingénierie Moléculaire des Protéines, CEA de Saclay, Gif-sur-Yvette, France
Crystal structure and functional domains of the Mambaquaretin-1, a vasopressin type 2 receptor peptide inhibitor for kidney cysts treatment
- 16h00 – 16h20: Alexandre CHENAL
Département de Biologie structurale et Chimie, Institut Pasteur, Paris, France
Calcium tightly regulates disorder-to-order transitions involved in the secretion, folding and functions of the CyaA toxin of Bordetella pertussis, the causative agent of whooping cough
- 16h20 – 16h40: Justyna CIOLEK
Service d’Ingénierie Moléculaire des Protéines, CEA de Saclay, Gif-sur-Yvette, France
Muscarinic toxin 9: a novel peptide from Dendroaspis polylepis venom that selectively targets muscarinic type 2 receptor
- 16h40 – 17h00: Romulo ARAOZ
Service d’Ingénierie Moléculaire des Protéines, CEA de Saclay, Gif-sur-Yvette, France
Vulcanodinium rugosum (French-isolate) producer of pinnatoxin-G, also synthesizes portimine, a potent inducer of apoptosis, that also acts as an antagonist of nicotinic acetylcholine receptors
- 17h00 – 17h10: Closure. Evelyne BENOIT (SFET President)
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