"Advances and new technologies in Toxinology"

13 et 14 Décembre 2010

Centre de conférence (CIS) - Institut Pasteur - Paris, France

Monday, 13 December

• 8h30 - 9h00 : Coffee

• 9h00 - 9h10 : Welcome. Denis SERVENT (SFET President)

9h10 - 11h20 :: Session “Genomic/Transcriptomic/Proteomic”

Chairmen : F. Ducancel - C. Legros

• 9h10 - 9h40 : Tim Stockwell (J. Craig Venter Institute, Rockville, USA)

  Sequencing the Genome of Conus consors – Preliminary Results

• 9h40 - 10h00 : Frédéric Ducancel (CEA, SPI, Gif sur Yvette, France)
  Animal toxin precursors cloning: from individual cloning to global transcriptomic studies

• 10h00 - 10h20 : Joel Doré (INRA, Jouy en Josas, France)
  The Human Intestinal Microbiota - from phylogenetics to functional metagenomics

• 10h20 - 10h40 : Pierre Bougis (IFR Jean Roche, Marseille, France)
  New developments for the characterization of scorpion venoms using nano-liquid chromatography and mass spectrometry

• 10h40 - 11h00 : Reto Stocklin (Atheris Laboratories, Genève, Switzerland)
  Venomics: targetted drug discovery

• 11h00 - 11h20: Loïc Quinton (Masse Spectrometry Laboratory, University of Liège, Belgium)
  New mass spectrometry approaches to study toxin-receptor interactions

11h20 - 11h40 : Coffee break & posters

11h40 - 16h30 :: Session “Detection/Neutralisation”
Chairmen : J. Molgó - L. Botana

1. 11h40 – 12h10: Philippe Hess (Ifremer, Nantes, France)
   Recent development in phycotoxins detection

2. 12h10 - 12h30 : Luis Botana (Universidad de Santiago de Compostela, Lugo, Spain)
   Current situation on receptor-based methods for marine toxins. Comparison with analytical solutions

12h30-14h10 : Lunch and Poster session

• 14h10 - 14h40 : Daniel Bertrand (CMU/ Dpt NEUF, Genève, Switzerland)

  The snake and the automate

• 14h40 - 15h00 : Philippe Billiald (MNHN & Faculté de Pharmacie de Paris-Sud, Paris, France)
  Scorpion antivenom: progresses and challenges

• 15h00 - 15h30 : Thibault Pelat (CRSSA, La Tronche, France)
  Development of humanized macaque antibodies to neutralize vegetal and bacterial toxins

• 15h30 - 15h50 : Eric Ezan (CEA, SPI, Gif sur Yvette, France)
  Detection of functional toxins of the biological threat by mass spectrometry

• 15h50 - 16h10 : Michael Seagar (Neurobiology of Ion Channels, Marseille, France)
  Protein chip assays for botulinum neurotoxins

• 16h10 - 16h30 : Hervé Volland (CEA, SPI, Gif sur Yvette, France)
  Portable detection kit for bioterrorism toxins

16h30 - 18h00 : General Assembly of the SFET

Tuesday, 14 December

8h30 - 9h00 : Coffee

9h00 - 12h30 Session “Structure/Interaction”

Chairmen : M. Delepierre - D. Servent 

• 9h00 - 9h30 : Marc Baldus (Bijvoet Center for Biomolecular Research, Utrecht University, The Netherlands)

  Studying ligand-protein interactions in membrane-embedded ion channels by NMR.

• 9h30 - 9h50 : Muriel Delepierre (Pasteur Institute, Paris, France)

  Toxin structures determination by NMR spectroscopy

• 9h50 - 10h10 : Rémi Fronzes (Pasteur Institute, Paris, France)

  Structural biology of bacterial type IV secretion systems

• 10h10 - 10h30 : Grazyna Faure (Pasteur Institute, Paris, France)

  Determination of Crystal Structures of ammodytoxin and crotoxin, two presynaptic Phospholipases A2: Impact of structural differences on their neurotoxic and anticoagulant function

• 10h30 - 10h50 : Bogdan Iorga (ICSN, CNRS, Gif sur Yvette, France)
  Structure and Dynamics of Spiroimine Toxins in Complex with Nicotinic Acetylcholine Receptors
  

10h50 - 11h20 : Coffee break & posters

• 11h20 - 11h50 : Christian Legros (UFR Sciences, Université d'Angers, France)

  Engineering KcsA-Kv1.x chimeric proteins for toxin-channel interaction studies

• 11h50 - 12h10 : Eric Trinquet (CisBio, Marcoule, France)
  New fluorescent technologies to monitor biomolecular events

• 12h10 - 12h30 : Michel Vivaudou (CEA/CNRS/UJF, IBS, Grenoble, France)

  Bio-inspired sensors based on the assembly of receptors and ion channels for label-free, real- time characterization of ligand-receptor interactions

• 12h30 - 12h50 : Pierre-Jean Corringer (Pasteur Institute, Paris, France)
  X-ray structure and allosteric regulation of bacterial channel-receptors homologous to nicotinic receptors

12h50-14h40 : Lunch and Poster session

14h40 - 17h40 : Session “Bacterial toxins-Miscellaneous”

Chairmen : M. Popoff/D. Ladant

• 14h40 - 15h10 : Pascale Cossart (Pasteur Institute, Paris, France)
  Listeriolysin O : more than a toxin, a potent signaling molecule !

• 15h10 - 15h40 : Kim Orth (UT Southwestern Medical Center, Dallas, USA)
  Black Spot, Black Death, Black Pearl: Tales of Bacterial Effectors

• 15h40 - 16h00 : Antigoni Alexandrou (Ecole Polytechnique, Palaiseau, France)
  Mapping the forces acting on receptors of pore-forming toxins inside cell membrane microdomains

• 16h00 - 16h20 : Mira Tawk (Institut de Bactériologie, Strasbourg, France)
  Staphylococcus aureus Gamma-hemolysin: more than just a pore forming toxin

• 16h20 - 16h40 : Caroline Stefani (Université de Nice-Sophia-Antipolis, Nice, France)
  Reorganization of the actin cytoskeleton in human endothelial cells infected by Bacillus anthracis

• 16h40 - 17h00 : Renaud Vincentelli (AFMB, Marseille, France)
  A new system for expression of recombinant toxins in E. coli

• 17h00 - 17h20 : Daniel Biass (Atheris Laboratories, Geneva, Switzerland)
  Rapid intra-specimen evolution of cone snail venom composition: multiplying pharmacological profiles ?

• 17h20 - 17h40 : Amparo Alfonso (Universidad de Santiago de Compostela, Lugo, Spain)
  The changing profile of marine toxins in Europe

17h40 : Closure. Denis SERVENT (SFET President)